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Thursday, December 1, 2011

Transplant Candidates Seek “Best Quality” Livers Despite Having to Remain on Waiting List


New research reveals that liver transplantation candidates want to be involved in decisions regarding quality of the donor organ, and many are reluctant to accept organs with a higher risk of failure. In fact, more than 42% of patients would choose to remain on the waiting list rather than accept a “lower quality” liver according to the study appearing in the December issue of Liver Transplantation, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases. 

As of November 30, 2011, the Organ Procurement and Transplantation Network (OPTN) reports that 16,124 candidates are on the waiting list to receive a liver, with only 5,375 deceased donor organs recovered through August. Additionally, there is a large variation in quality of deceased donor livers, which is based on donor characteristics such as age, cause of death, and ischemia time. Previous research has shown that donor characteristics can make the difference between a 20% to 40% risk of graft failure by 3 years following transplantation. 

“Organ quality is an important issue for all liver transplant candidates, increasingly so, given the aging donor pool and more frequent use of organs that carry a higher risk of failure,” explains Dr. Michael Volk with the University of Michigan Health System in Ann Arbor. “The decision to accept or pass on an organ could mean the difference between life and death for patients with end-stage liver disease. Communication of the risks versus benefits of accepting a “lower quality” organ is critical, and understanding patient views on the subject is essential for physicians caring for transplant candidates.” 

For the current study, researchers tested presentation formats for communicating organ quality risks to patients, and factors that might influence patients’ willingness to accept higher risk organs. First, the team conducted interviews with ten patients on the waiting list for liver transplantation to determine their knowledge of organ quality and preferences for accepting organs with greater risk of failure. Based on qualitative information obtained from interviews, the team created a web-based survey which 95 candidates completed. 

The findings show that patients are reluctant to accept higher risk organs, wanting only the “best” organ. Of those completing the survey, 58% would only accept organs with a 25% (or less) risk of graft failure and 18% would only accept the lowest possible risk of 19% at 3 years following transplantation. Women were slightly more accepting of high risk organs than men. Researchers found that risk tolerance was increased by presenting organ quality as “average quality” rather than “best quality,” and by providing feedback about the implications of these preferences on the likelihood of receiving a transplant. Additionally, 83% of candidates were found to prefer an equal or dominant role in deciding whether to accept a higher risk organ. This finding is striking given that, in most transplant centers, patient involvement in these decisions is minimal. 

“Up until now, it has not been clear how much patients want to be involved in this complicated decision,” says Dr. Volk. “Furthermore, explaining the intricacies of this topic to sick patients is easier said than done. Our findings offer transplant physicians some useful guidelines for how to council transplant candidates on issues of organ quality.” The authors suggest future studies are needed to develop validated patient education tools that will enhance discussions between physicians and patients in need of liver transplantations.

This study is published in Liver Transplantation. Media wishing to receive a PDF of the article may contact healthnews@wiley.com.
 Full citation: Patient Decision Making about Organ Quality in Liver Transplantation.” Michael L. Volk, Rachel S. Tocco, Shawn J. Pelletier, Brian J. Zikmund-Fisher and Anna S. F. Lok. Liver Transplantation; Published Online: November 29, 2011 (DOI: 10.1002/lt.22437) Print Issue Date: December 2011. http://onlinelibrary.wiley.com/doi/10.1002/lt.22437/abstract.
Author Contact:To arrange an interview with Dr. Volk, please contact Mary Masson with the University of Michigan at mfmasson@med.umich.edu .

About the Journal
Liver Transplantation. is published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society . Since the first application of liver transplantation in a clinical situation was reported more than twenty years ago, there has been a great deal of growth in this field and more is anticipated. As an official publication of the AALSD and the ILTS, Liver Transplantation. delivers current, peer-reviewed articles on surgical techniques, clinical investigations and drug research — the information necessary to keep abreast of this evolving specialty. For more information, please visit Liver Transplantation


About Wiley-Blackwell
Wiley-Blackwell is the international scientific, technical, medical, and scholarly publishing business of John Wiley & Sons, with strengths in every major academic and professional field and partnerships with many of the world’s leading societies. Wiley-Blackwell publishes nearly 1,500 peer-reviewed journals and 1,500+ new books annually in print and online, as well as databases, major reference works and laboratory protocols. For more information, please visit www.wileyblackwell.com or our new online platform, Wiley Online Library (wileyonlinelibrary.com), one of the world’s most extensive multidisciplinary collections of online resources, covering life, health, social and physical sciences, and humanities.

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