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Wednesday, November 23, 2011
Plasma MicroRNA Panel ID’d for Diagnosing Hepatocellular Cancer
Jian Zhou, M.D., Ph.D., from Fudan University in Shanghai, China, and colleagues sought to identify plasma microRNAs for diagnosing HBV-related HCC. A total of 934 participants, including healthy individuals, and those with chronic hepatitis B, cirrhosis, and HBV-related HCC, were selected between August 2008 and June 2010. Initially, 723 microRNAs in 137 plasma samples were screened using a microarray to diagnose HCC. The expression of selected microRNAs was subsequently evaluated using a quantitative reverse-transcriptase polymerase chain reaction assay. A training cohort comprising 407 individuals was used to create a logistic regression model, which was then validated using an independent cohort of 390 individuals. The diagnostic accuracy was assessed using the area under the receiver operating characteristic curve (AUC).