In patients who have chronic hepatitis C and undergo liver biopsy, the presence of Mallory-Denk bodies – hepatocyte cytoplasmic inclusions that occur in several chronic liver diseases – is independently associated with progression of liver fibrosis, Dr. Mina O. Rakoski and her colleagues reported in the October issue of Clinical Gastroenterology and Hepatology.
In addition, patients in whom serial liver biopsies show an increase in the number of Mallory-Denk bodies over time are more likely to have clinical decompensation and progression to cirrhosis than patients who have no Mallory-Denk bodies or who have a stable or decreasing number of them over time.
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