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Alan Franciscus
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HCV Advocate
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Saturday, October 1, 2011

Deferasirox Can Improve Liver Fibrosis, Necroinflammation

Treatment with the iron chelator deferasirox for at least 3 years stabilized or improved liver fibrosis and necroinflammation and also reduced serum alanine aminotransferase levels in patients with beta-thalassemia and iron overload, Dr. Yves Deugnier and his colleagues reported in the October issue of Gastroenterology.

This improvement occurred independently of patients’ treatment response as measured by liver iron concentration, which suggests that some of the drug’s benefit is independent of its iron-clearing ability. The improvements also were seen regardless of patients’ hepatitis C virus (HCV) antibody status at baseline, said Dr. Deugnier of University Hospital Pontchaillou in Rennes, France, and his associates (Gastroenterology 2011 October [doi:10.1053/j.gastro.2011.06.065]).

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